A section of the A169 road between Whitby and Pickering is closed while police deal with a “serious” accident.
It is between the Hole of Horcum and the Lockton turn-off.
A police spokesman said: “Emergency services are currently dealing with a serious crash between a car and a lorry on A169 Whitby to Pickering road.
“It happened at around 2.35pm today between the Hole of Horcum and Lockton.
“Ambulance and fire crews have been attending to three casualties. A man and a woman in the car, and a man driving the HGV.
“Local diversions have been put in place to allow to the police to investigate the scene and for the vehicles to be recovered.
“Witnesses are asked to contact North Yorkshire Police on 101, select option 1, and speak to the Force Control Room. Please quote reference NYP-01032016-0256.”