It is the first year the event, which was previously held at Whitby Pavilion, is being held in the resort on 17 to 19 October at the 3,500 capacity venue.
Among the 30 acts booked to appear are Grammy award-winning Malian kora player Toumani Diabaté who has worked with Bjork, Damon Albarn and Taj Majal, who will headline the festival, along with The Levellers, Rolf Harris, Ska Cubano and Ivo Papasov and his Wedding Band.
Other musicians at the three day festival include legendary drummer Billy Cobham and Asere (Cuba/USA), The Warsaw Village Band, Moussu TE Lei Jovents and desert blues band Etran Finatawa (Niger).
Headliner Toumani Diabaté, recently appeared on the BBC TV show, Later with Jools Holland, and is considered one of the world's best players of the kora, a 21-string African harp.
He will be bringing a group of his musicians with him.
And the Levellers will also celebrate their 20th anniversary at Musicport. The band made its name campaigning against the Thatcher Government during the 80s and protesting against UK road-developments in the 90s.
Rolf Harris will mark his debut at Musicport, having already graced stages at WOMAD and Glastonbury.
Palestinian singer, musician and broadcaster Reem Kelani returns to the festival this year.
Her debut album Spring Gazelle, released in 2006, brought her critical acclaim after 20 years work she had invested into research into traditional Palestinian songs. In a rare UK performance, Moussu TE Lei Jovents will demonstrate their particular take on the music of coastal Marseille.
Ivo Papasov will be flying in from Bulgaria with his Wedding Band, demonstrating why listeners voted for him to win the BBC Radio 3 World Music Audience Award in 2005 and why Frank Zappa was a huge fan.
Of Bulgarian Roma and Turkish heritage, Papasov's music draws on Balkan Gypsy culture.
Festival director Jim McLaughlin said the festival has a line-up that people will travel miles to see and has all of the usual upbeat, life-affirming music that keeps people returning to Musicport year on year.
The musical bill will be complemented by dance/drama from the Kathakali Theatre Company from Kerala, India.
As well as two main stages there will be a DJ room, a visual arts and a workshop area, a festival club, film programme, children's festival, an expanded market area, and Musicport's first silent disco.
Tickets are available online at www.musicportfestival.com or by calling (0845) 3732760.
Adult tickets cost from £75 at an early bird discount. Children under 11 years go free.